INDIANAPOLIS & GREENWOOD • PHYSICIAN-LED
IV Ketamine Therapy for Depression in Indianapolis & Greenwood
If you’ve tried the antidepressants and the therapy and still feel like you’re watching your own life through glass, you’re not out of options. We treat depression at the neurological root with physician-led IV ketamine, plus the brain-health work that makes it hold.
5,000+
IV Infusions Performed
25+ yrs
Physician Experience
65–70%
Avg. Depression Score Drop
4.9★
Google Rating (109+ reviews)
Symptom-score data based on AlphaOmega Wellness treatment records, 2018–2026, using PHQ-9 and GAD-7. Individual results vary.
IF THIS SOUNDS FAMILIAR
You Took the Kids Somewhere Fun and Just Wanted to Go Home.
When that happens, it’s not a character flaw and it’s not the end of the list. It has a name: treatment-resistant depression. And it means the approach needs to change, not that you’re beyond help.
They’re slow
SSRIs and SNRIs can take four to six weeks to kick in. When you’re barely getting through the day, that’s a long time to wait for a maybe.
They don’t work for everyone
Roughly 30% of people don’t respond adequately to standard antidepressants, and many more get only partial relief.
The side effects
Weight gain, emotional blunting, insomnia, low libido. The list of reasons people quit their meds is long and real.
They treat the surface
Most antidepressants nudge serotonin. They don’t rebuild the brain wiring that chronic depression actually damages.
THE MECHANISM
How IV Ketamine Lifts Depression at the Brain Level
And for days after each infusion, your brain sits in a window where it’s primed to rewire. That’s where the real work happens.
A different system entirely
By working on glutamate and NMDA receptors, ketamine reaches depression through a pathway standard meds don’t touch.
It rebuilds connections
Ketamine triggers BDNF and neuroplasticity, helping your brain regrow the connections chronic stress wears down.
It works fast
Many people feel a real lift within 24 to 72 hours of the first infusion, not weeks or months later.
It quiets the loop
Ketamine helps calm the default mode network, the source of the 3am rumination and negative self-talk.
WHAT WE TREAT
Forms of Depression We Treat
Treatment-Resistant Depression
When two or more antidepressants haven’t worked, ketamine’s different mechanism is exactly what it was developed for.
Major Depressive Disorder
The heavy, persistent fog that drains energy and steals joy. Ketamine targets the biology underneath it.
Grief & Situational Depression
Loss, divorce, burnout, a hard diagnosis. When the low outlasts the event and won’t lift on its own, ketamine can help you get traction again.
Bipolar Depression
The depressive side of bipolar can be the hardest to treat. Ketamine is worth exploring with our physician-led team.
WHAT TO EXPECT
What Depression Treatment Actually Looks Like
1. Free consult
A real, unhurried conversation. We review your history, meds, and what you’ve already tried to see if IV ketamine is a fit.
2. Your protocol
Most patients do 6 infusions over 2 to 3 weeks, about 40 minutes each, in a quiet private room in Greenwood.
3. Monitored throughout
Your provider and the clinical team watch your vitals from start to finish, every session.
4. Integration support
We help you use the neuroplasticity window between and after sessions so the lift turns into lasting change.
QUESTIONS PEOPLE ACTUALLY ASK
Depression + IV Ketamine: Your Questions
What is treatment-resistant depression?
It’s major depression that hasn’t responded adequately to at least two different antidepressants, each tried at the right dose for enough time. It affects about 30% of people with major depression. If that’s you, you’re not alone, and IV ketamine was developed with exactly this in mind.
How is IV ketamine different from antidepressants?
Antidepressants mostly work on serotonin and take four to six weeks. IV ketamine targets glutamate and NMDA receptors, triggering neuroplasticity. That different pathway is why it can help people who didn’t respond to standard meds, often within 24 to 72 hours.
How many infusions will I need?
The standard start is six infusions over three to four weeks. Many people feel a difference by the second or third. After the series, occasional boosters help maintain results. We personalize the plan to you.
How quickly does it work?
Many patients notice mood improvement within 24 to 72 hours of the first infusion. There’s no four-to-six-week wait, and the benefit builds across the full series.
Is it safe?
Yes. In a supervised medical setting it has a strong safety profile. Every infusion is overseen by your provider and the clinical team, who monitor your vitals throughout. Temporary effects like mild dissociation or nausea resolve within 15 to 30 minutes.
How much does it cost?
It depends on your personalized plan. We accept HSA and FSA and offer flexible payment options. The free consult is the best place to get real numbers. See our financing options.
Do you treat patients from outside Indianapolis?
Absolutely. Patients come from Greenwood, Carmel, Fishers, Noblesville, Westfield, Avon, Brownsburg, Plainfield, Mooresville, Southport, Bargersville, and across Central Indiana. Our Greenwood clinic is easy to reach from I-65.
Ready to feel like yourself again?
Book a free consult and we’ll tell you honestly whether IV ketamine is a fit for your depression. We’ll cover pricing, financing, HSA/FSA, and first-responder and veteran discounts on the call. No pressure, no hard sell.
Serving Indianapolis, Greenwood, Carmel, Fishers, Noblesville, Westfield, Avon, Brownsburg, Plainfield, Mooresville, Southport, Bargersville and all of Central Indiana.
AlphaOmega Wellness • 1777 W. Stones Crossing Rd, Suite 140, Greenwood, IN 46143 • Call or text 317-300-4091
Medically reviewed by Dee Bonney, MD — Board-Certified Emergency Medicine, Medical Director, AlphaOmega Wellness. Last reviewed: August 2026. Meet our team →