IV Ketamine Therapy for Depression, Anxiety, and PTSD

Struggling with treatment-resistant depression, anxiety, or PTSD? At AlphaOmega Wellness, we offer fast-acting ketamine therapy, providing hope and symptom relief when traditional treatments fall short.

Discover how ketamine therapy can break the cycle and help you reclaim your mental health.

Most antidepressants work on serotonin. You take one daily and wait four to six weeks to find out if it was the right one. If it was not, you start over.

Ketamine works somewhere else entirely.

People come to us after a long stretch of things not working. Several medications, often years, sometimes therapy that helped them understand it without lifting it.

• Treatment-resistant depression — at least two medications that did not work. The single most common reason people call us.
• Depression — including the functional, invisible kind you have been carrying to work every day.
• Anxiety — especially when it runs alongside depression rather than on its own.
• PTSD — including first responders and veterans. We came out of the emergency department, so this is not an abstraction to us.

Strange. Usually not scary.

Ketamine has been used in medicine since 1970, most often as an anesthetic, at doses far higher than anything used for depression. What it does do, briefly, is affect blood pressure, heart rate, perception and coordination. That is exactly why it belongs in an office with monitoring rather than at a kitchen table.

• Common side effects — nausea, dizziness, dissociation, blurred vision, fatigue, briefly elevated blood pressure. Most fade within an hour of the infusion ending.
• Who we screen out — certain cardiac histories, uncontrolled blood pressure, pregnancy and some psychiatric histories. Screening is a real part of the consult, not a formality.
• Someone is with you the whole time — blood pressure, heart rate and oxygen are monitored, and every member of our staff is trained in psychedelic trip sitting, so the person beside you knows what to do when the experience gets big, not just when the numbers do.
• At-home ketamine is a lot less supervised — lozenges mailed to your door are the same medication with far less oversight. Nobody is checking your blood pressure and nobody is in the room if it gets difficult. Dr. Bonney made a video about where unsupervised ketamine can lead, and the full comparison is here.

Fair question, and the honest answer has two halves.

This is the part most clinics summarize in three bullets. Here is the whole thing.

• A full evaluation. Medical and mental health history, a medication review, what you have already tried and how you responded, symptoms measured with standardized screening tools, and a check for anything that would make ketamine the wrong call. Then informed consent, an actual conversation about risks and what to expect, not a signature on a clipboard.
• Dosing that follows published standards, not gut feeling. We start with weight-based dosing, then adjust across the series based on how you respond and what you tolerate. We follow the ASKP3 consensus guidelines, the national standards for IV ketamine set by the American Society of Ketamine Physicians, Psychotherapists and Practitioners. Plenty of clinics dose on instinct. We do not.
• An induction series of six, not a single infusion. Six IV infusions, usually over two to three weeks, each about forty minutes. The neuroplastic changes are cumulative. One infusion can create relief. A series is what creates change.
• Infusion days you are never left alone on. Baseline vitals and a symptom check, IV placement by trained medical staff, continuous monitoring, provider oversight on site, and a recovery period before you go home. This is not self-administered care, and you will need a ride.
• Tracking between infusions, not just at the end. Your response is measured as you go, and the plan moves with it.
• Integration, because the window closes. Ketamine opens something up. What you do next decides what it turns into. Every patient is supported through our ROOT framework: regulating the nervous system, addressing the physical barriers in the way, keeping the window open, and doing the work of changing patterns that are not serving you. Ketamine used in isolation is half a treatment.
• An honest answer about what comes next. After the induction series we look at your symptom scores, your function, and how stable the response is, then decide whether maintenance infusions make sense and how far apart. Some people need occasional boosters. Some do not. There is no forever schedule here.

What this is not. Not at-home ketamine, not self-directed dosing, not a spa treatment, and not a one-visit fix.

“I’ve been on a journey to see what could make me better, and I think ketamine was the thing I needed first. I’m less taken down by the hard things. Like life throws you punches, but it doesn’t take me all the way out…  I don’t feel like I’m spiraling any more. I have more power to work though.”

– TN

Ketamine therapy is a safe and effective treatment for various mental health conditions, offering a new approach for those who haven’t found relief with traditional methods.

Indiana’s Only Legal Psychedelic

Discover effective ketamine therapy for depression and anxiety at AlphaOmega Wellness in Greenwood, IN