KETAMINE INTEGRATION • GREENWOOD, INDIANA
Healing Happens Beyond the Chair.
The infusion is the icing. The cake is what happens outside the chair — in your everyday life, during the neuroplasticity window your treatment opened.
We built Brain Health Reboot and ROOT so you know exactly what to do with it.
OUR PHILOSOPHY
We Don’t Just Open the Window. We Teach You What to Do With It.
When ketamine triggers neuroplasticity, your brain opens a window — a period where new synaptic connections can form, old patterns can shift, and a different way of operating becomes possible.
What you do inside that window determines how much of the healing sticks.
Ketamine integration is the work of that window. Most clinics hand you an infusion and send you home. We built an entire curriculum around what happens next.
The Neuroplasticity Window
After each infusion, your brain enters a heightened period of neuroplasticity. New neural connections are forming. Old patterns are loosening. This window is the most important time to take action — even small actions compound powerfully here.
Action Over Insight
The Next Right Thing
THE NEUROSCIENCE
What’s Actually Happening in Your Brain
Depression, anxiety, and PTSD aren’t just feelings. They change the brain in real, physical ways.
When stress goes on for a long time, the tiny connection points between brain cells (called dendritic spines) start to shrink. This happens in the brain areas that handle focus, mood, and hope (the prefrontal cortex and hippocampus). That’s part of why those things get harder to reach over time. It isn’t a flaw in who you are. It’s a change in how the brain is wired.
Ketamine helps rebuild those connections (synapses). It blocks a receptor called NMDA, which sets off a chain that raises a growth factor called BDNF and helps new connections form. In lab studies, this began within hours of a single dose — a real, physical change, not just a shift in mood (Li et al., Science, 2010).
That’s what we mean by “the window.” It’s real, not just a figure of speech. For a short time after each infusion, the brain can build and strengthen connections better than it could the week before.
Here’s the part most people are never told: the open window (a period of high plasticity) doesn’t decide what gets built. Your brain strengthens whatever you practice during that time — even old patterns, if nothing changes. New, healthier patterns don’t build themselves. What you actually do in the window is what has the best chance of sticking.
That’s why integration isn’t just an add-on at AlphaOmega Wellness. It’s the part of treatment that decides what the window gets used for.
THE WINDOW, DAY BY DAY
What to Expect — and What to Do
Infusion Day — Rest
Your brain is doing work you cannot feel yet. No driving, no major decisions, no hard conversations. Low input. Quiet. Sleep is productive here.
Days 1–3 — Peak Plasticity
The highest-leverage days of the entire series. Small actions land differently now. The walk. The text you have been avoiding. The boundary you have needed to set. This is when to do the next right thing — even if your mood has not caught up yet.
Days 4–7 — Consolidation
The acute plasticity tapers, but whatever you started this week is actively encoding. Repetition matters more than intensity. Doing the small thing again beats doing a bigger thing once.
Between Infusions
Emotions can surface here, and that is normal — sometimes it feels worse before it feels better. This is where patients drift without structure, and where journaling, group, and coaching do the most work.
After Your 6th Infusion
The series ends. What remains is what you built. Boosters, maintenance, and continued practice are planned around your response — not a fixed schedule.
Months 2–6 — The Long Game
Nervous system regulation, sleep, inflammation, blood sugar, boundaries. The unglamorous inputs that decide whether your gains hold. This is what ROOT+ exists for.
INCLUDED WITH EVERY KETAMINE SERIES
🧠 Brain Health Reboot
A full integration curriculum that walks you through every stage of your ketamine journey. From your very first infusion to what comes after your sixth. Built around the questions patients actually have, the fears that show up at 2am, and the practical tools that make the difference between a good experience and lasting change.
No other clinic in Indiana provides this level of support between and after infusions.
Before Your First Infusion
Setting intentions, preparing your nervous system, managing anxiety, and approaching your treatment so the medicine can do its best work.
Right After Your Infusion
Do I need to remember it? Why did I cry? Am I doing this right? What if I don’t feel anything? Every question patients ask at 2am — answered.
Between Infusions
Journaling, small actions that build big patterns, protecting the neuroplasticity window, working with a therapist, how to use insights without overthinking them.
Using the Window
Notice the pattern. Insight vs. integration. Inputs and capacity. Your nervous system emergency kit.
Ketamine 101
What ketamine actually does in the brain, why it’s not about the psychedelic experience, and why the series of 6 matters.
After Your 6th Infusion
What to do next, booster education, and what long-term brain health actually looks like.
ONGOING BRAIN HEALTH
ROOT
Long-term brain health isn’t built in one infusion series or one insight. It’s built through rhythm, repeated tools, nervous system practice, and continued support while your brain keeps changing. ROOT is built around four pillars.
🔵 Regulate
Your nervous system is the foundation. Polyvagal theory, emotional awareness, sleep, breathing, and practical resets — including a 5-day nervous system reset and 7-day overstimulation detox.
🔴 Overcome
Brain health is biological. Inflammation, blood sugar, cortisol, and gut-brain disruption all drive depression and anxiety. We address what most mental health treatment ignores.
🟠 Open
Neuroplasticity meets daily life. Habits and patterns, insight vs. change, body movement, shadow work, and a 5-day identity shift challenge.
🟢 Transform
Emotions, boundaries, grief, trauma, moral injury vs. PTSD, and adverse childhood experiences. Understanding what’s running the patterns — and what to do about it.
ALREADY HAVE A THERAPIST?
Good. We Work Alongside Them.
Your therapist knows you — your history, your patterns, the deeper work that takes time and trust to uncover. That relationship is irreplaceable, and we’d never try to replicate it.
What Brain Health Reboot and ROOT provide is different: an educational framework built around CBT, DBT, and ACT skills, the neuroscience of what’s happening in your brain during and after ketamine, and practical tools you can use every day between sessions.
Your therapist works with your story. We teach you how to work with your brain.
The research is consistent: ketamine combined with active skills-based support produces better, more lasting outcomes than ketamine alone. Many of our patients bring what they learn in Brain Health Reboot directly into their therapy sessions. Their therapists love it.
COMMON QUESTIONS
Questions About Integration
How long does the neuroplasticity window actually last?
Research on ketamine’s effect on synaptic plasticity points to changes beginning within hours and the most pronounced effects in roughly the first several days after an infusion. Clinically, we treat the first 24 to 72 hours as the highest-leverage window, with continued benefit through the first week. Because you receive a series rather than a single dose, these windows stack — which is a large part of why the series of six matters.
Do I have to do the integration work for ketamine to help me?
Many patients feel meaningful relief from the infusions alone. The honest answer is that relief and durability are two different questions. Ketamine reliably opens the window; what fills that window is what tends to determine how long the change holds. Integration is how you turn a good few weeks into a different baseline.
What if I don’t feel like doing anything after my infusion?
That is expected, and it is the entire point of how we teach this. Your mood will keep making its case for staying on the couch — that pattern took years to build. Integration is not about waiting to feel motivated. It is about following through on the thought anyway, at the smallest possible scale. Five minutes. One walk. The next right thing, not everything.
Is Brain Health Reboot an extra cost?
No. Brain Health Reboot is included with every IV ketamine series at AlphaOmega Wellness. It is not an upsell — it is part of how we practice. ROOT is our ongoing program for patients who want to keep building after the series ends.
Is integration the same thing as therapy?
No. Brain Health Reboot and ROOT are educational, not therapy, and they do not replace a therapist. They teach the neuroscience of what is happening in your brain and give you practical skills drawn from CBT, DBT, and ACT frameworks that you can use between sessions. If you have a therapist, this works alongside them.
Who supervises the medical side of treatment?
Every infusion is conducted under the medical direction of Dr. Dee Bonney, MD — a board-certified emergency physician with 25+ years of experience — with a paramedic present at all times. Our staff aren’t just ACLS-trained. They’re working paramedics. That card isn’t gathering dust in a wallet — these are people who use those skills regularly in the field. Vital signs are monitored continuously throughout every session.
The infusion opens the door. We help you walk through it.
If you’re considering ketamine therapy and want to understand not just the infusion but the full arc of what healing looks like — the chair, the window, and everything that comes after — start here.
Or call us at 317-300-4091 — AlphaOmega Wellness, Greenwood, Indiana
The Clinical Evidence Behind IV Ketamine
Our care is grounded in peer-reviewed research on ketamine’s mechanism and outcomes:
- Li N, et al. mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists. Science. 2010. PubMed
- Zarate CA, et al. A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression. Arch Gen Psychiatry. 2006. PubMed
- Murrough JW, et al. Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial. Am J Psychiatry. 2013. PubMed
- Wilkinson ST, et al. The effect of a single dose of intravenous ketamine on suicidal ideation: a systematic review and IPD meta-analysis. Am J Psychiatry. 2018. NIH / PMC
- Feder A, et al. Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial. JAMA Psychiatry. 2014. PubMed
This information is educational and not a substitute for individualized medical advice. IV ketamine is FDA-approved as an anesthetic and used off-label for mood disorders. Individual results vary.
Medically reviewed by Dee Bonney, MD — Board-Certified Emergency Medicine, Medical Director, AlphaOmega Wellness. Last reviewed: July 2026. Meet our team →