If you have been living with depression, anxiety, or PTSD and feel like you have tried everything — therapy, medications, lifestyle changes — without lasting relief, you are not alone. Millions of Americans struggle with treatment-resistant mental health conditions, and the cycle of switching from one medication to the next can leave you feeling hopeless. AlphaOmega Wellness is a physician-led IV ketamine therapy clinic serving the greater Indianapolis area from our Greenwood, Indiana location, and we specialize in helping patients just like you find a new path forward. We offer free consultations so you can learn whether IV ketamine therapy is the right fit before committing to anything.
What Is IV Ketamine Therapy?
Ketamine is an FDA-approved anesthetic that has been used safely in hospitals and surgical centers for over fifty years. In recent decades, researchers discovered that ketamine, administered at lower sub-anesthetic doses, produces rapid and significant improvements in symptoms of depression, anxiety, PTSD, and other mood disorders. These findings have made ketamine one of the most exciting breakthroughs in mental health treatment in a generation.
Unlike traditional antidepressants such as SSRIs and SNRIs — which target serotonin and norepinephrine and can take four to six weeks to show results — IV ketamine works on the brain’s glutamate system and NMDA receptors. This mechanism triggers a process called neuroplasticity, where the brain rapidly forms new neural connections. Many patients who receive IV ketamine therapy in Indianapolis report feeling a noticeable shift in their mood within hours or days rather than weeks.
For the millions of people whose depression or anxiety has not responded to standard medications, IV ketamine offers genuine hope. Clinical studies consistently show that ketamine can provide relief where other treatments have failed, making it an important option for anyone dealing with treatment-resistant depression in Indianapolis or the surrounding Central Indiana communities.
Conditions We Treat With IV Ketamine in Indianapolis
At AlphaOmega Wellness, we use IV ketamine therapy to treat a range of mental health conditions that have not responded well to conventional approaches. Our physician-led team evaluates every patient individually to ensure ketamine is the right fit for your specific needs.
Depression
IV ketamine therapy has shown remarkable results for patients with treatment-resistant depression — those who have tried two or more antidepressant medications without adequate improvement. Rather than waiting weeks for a traditional antidepressant to take effect, many patients experience rapid symptom relief after their first or second ketamine infusion. If depression has kept you from engaging fully in your life, career, or relationships, ketamine for depression in Indianapolis at AlphaOmega Wellness may offer the breakthrough you have been searching for.
Anxiety
Chronic anxiety — whether it presents as generalized anxiety disorder, panic disorder, or social anxiety — can be debilitating. IV ketamine helps by essentially resetting the overactive neural pathways that keep the brain locked in a state of heightened alertness and fear. Patients receiving ketamine for anxiety in Indianapolis at our clinic often describe a sense of calm and clarity that they have not felt in years, sometimes after just a single session.
PTSD
Post-traumatic stress disorder affects veterans, first responders, survivors of abuse, and anyone who has experienced significant trauma. Ketamine’s neuroplasticity effect allows the brain to form new pathways around traumatic memories, helping patients process and move beyond experiences that have kept them stuck. AlphaOmega Wellness is proud to offer ketamine for PTSD in Indianapolis, and we provide first responder discounts as a small way to give back to those who serve our community.
Burnout & Brain Fog
Executive burnout, chronic stress, and persistent brain fog are increasingly common in today’s demanding world. When you cannot concentrate, make decisions, or find motivation despite knowing something is off, it takes a toll on every area of your life. At AlphaOmega Wellness, we take a personalized approach to address burnout and cognitive fog, using IV ketamine therapy alongside our broader wellness offerings to help you reclaim mental sharpness and resilience.
OCD
Obsessive-compulsive disorder can be incredibly resistant to standard treatments, leaving patients trapped in exhausting cycles of intrusive thoughts and compulsive behaviors. Emerging research suggests that IV ketamine may help interrupt these patterns by promoting new neural connections that reduce the rigidity of OCD thought loops.
What to Expect During Your IV Ketamine Treatment
Your journey at AlphaOmega Wellness begins with a free consultation. During this initial visit, our team — led by Dr. Dee Bonney and Megan Bonney, PMHNP — will review your medical history, discuss your current symptoms and treatment history, and help you understand whether IV ketamine therapy is the right next step. We believe every patient deserves a personalized plan, not a one-size-fits-all protocol, and this consultation is where that plan begins.
Each IV ketamine infusion takes approximately 40 minutes and is administered in a comfortable, medically supervised setting at our Greenwood clinic. You will be seated in a relaxing environment while the ketamine is delivered directly into your bloodstream through an IV line. During the infusion, patients typically experience a calm, dream-like state. Some people describe mild floating sensations or gentle shifts in perception. Our clinical team monitors you throughout the entire session to ensure your safety and comfort.
After your infusion, you will remain in our clinic for a brief observation period of approximately 30 minutes. This gives our team time to ensure you are feeling stable before heading home. You will need to arrange for someone to drive you, as you should not operate a vehicle after your session. We recommend resting for the remainder of the day to allow the full benefit of the treatment to take effect.
A typical course of treatment involves a series of six infusions administered over a period of three to four weeks. This initial series is designed to build on each session’s progress, with many patients noticing cumulative improvement as they move through their treatments. After completing the initial series, some patients benefit from periodic booster infusions to maintain their results. Your care team will work with you to determine the ideal schedule based on your individual response.
IV Ketamine vs. Other Ketamine Treatments
Not all ketamine treatments are created equal, and understanding the differences can help you make an informed decision about your care. IV ketamine delivers the medication directly into your bloodstream, providing 100 percent bioavailability — meaning your body absorbs the full dose with precision. Oral ketamine, by contrast, must pass through the digestive system, where absorption is less predictable and bioavailability can drop significantly. This means IV delivery offers more consistent, reliable results from session to session.
You may have also heard of Spravato, which is an FDA-approved nasal spray form of esketamine designed specifically for treatment-resistant depression. Spravato has the advantage of being covered by some insurance plans, making it a more accessible option for certain patients. However, IV ketamine allows your provider to adjust the dose in real time during the infusion, offering a level of precision and customization that nasal delivery cannot match. At AlphaOmega Wellness, we offer both IV ketamine and can help guide you toward the treatment modality that fits your clinical needs and budget.
For most patients seeking rapid, reliable relief from depression, anxiety, or PTSD, IV ketamine remains the gold standard. Its full bioavailability, real-time dose control, and decades of clinical evidence make it the preferred choice among physician-led ketamine therapy clinics in Indianapolis and across the country.
Why Choose AlphaOmega Wellness for Ketamine Therapy in Indianapolis?
AlphaOmega Wellness is not a franchise, a med spa add-on, or an urgent care clinic experimenting with ketamine on the side. We are a family-owned, faith-based practice founded by Dr. Dee Bonney, a board-certified physician, and Megan Bonney, PMHNP, a psychiatric nurse practitioner. Having both a physician and a psychiatric NP on staff means your care is guided by deep medical expertise and specialized mental health training — a combination that is rare among ketamine clinics in the Indianapolis area.
Our track record speaks for itself. With more than 1,000 infusions performed and a success rate exceeding 70 percent, we have helped hundreds of patients across Central Indiana find meaningful relief from conditions that once felt unmanageable. Every treatment plan we create is individualized, because we know that no two patients respond to ketamine in exactly the same way. Your dosing, session frequency, and follow-up care are all tailored to you.
We also believe that access to effective mental health care should not be limited by financial barriers. AlphaOmega Wellness accepts HSA and FSA payments, offers first responder discounts, and provides free consultations so you can explore your options without pressure. We are committed to making physician-led ketamine therapy in Indianapolis as accessible and approachable as possible.
Our Greenwood, Indiana clinic is conveniently located to serve patients throughout the greater Indianapolis area. Whether you are coming from Carmel, Fishers, Noblesville, Westfield, Avon, Brownsburg, Plainfield, Mooresville, Southport, or Bargersville, compassionate, expert ketamine care is within reach.
Frequently Asked Questions About IV Ketamine Therapy in Indianapolis
How much does IV ketamine therapy cost in Indianapolis?
A typical course of IV ketamine therapy involves a series of six infusions, and the total investment varies depending on your individual treatment plan. At AlphaOmega Wellness, we accept HSA and FSA payments to help offset costs and keep care accessible. The best way to understand pricing and explore your options is to schedule a free consultation with our team, where we can discuss your specific needs and provide transparent cost information with no obligation.
Is IV ketamine therapy covered by insurance?
Most insurance plans do not currently cover IV ketamine therapy, as it is considered an off-label use of the medication for mental health purposes. However, AlphaOmega Wellness accepts HSA and FSA funds, and we can provide documentation that may assist with reimbursement claims. We believe that the investment in your mental health now can prevent far greater personal, professional, and financial costs down the road.
What are the side effects of IV ketamine therapy?
The most common side effects during an IV ketamine infusion include temporary feelings of dissociation, mild dizziness, and occasional nausea. These effects are typically short-lived and resolve within minutes after the infusion ends. All sessions at AlphaOmega Wellness are administered in a supervised clinical setting with continuous monitoring, so our team is always on hand to ensure your comfort and safety throughout the treatment.
How quickly will I feel results?
Many patients notice improvements in their mood and symptoms within 24 to 72 hours of their first IV ketamine infusion. This rapid onset of relief is one of the most significant advantages ketamine holds over traditional antidepressants, which can take weeks to produce noticeable changes. The full benefit of treatment often becomes apparent after completing the initial series of six infusions, though individual results can vary.
Am I a good candidate for IV ketamine therapy?
IV ketamine therapy is generally best suited for patients with treatment-resistant depression, anxiety, PTSD, or other mood disorders who have not found adequate relief through conventional medications or therapy. It may also be appropriate for individuals dealing with OCD, chronic burnout, or cognitive difficulties. The most reliable way to determine whether you are a good candidate is to schedule a free consultation at AlphaOmega Wellness, where our clinical team will review your history and help you make an informed decision.
Can I drive after my IV ketamine session?
No. Due to the effects of ketamine, you will not be able to drive yourself home after your infusion. Please arrange for a friend, family member, or rideshare service to pick you up from our clinic. We also recommend resting for the remainder of the day following your session to allow the treatment’s full effects to settle in.
Do you serve patients outside of Indianapolis?
Absolutely. While our clinic is located in Greenwood, Indiana, we regularly serve patients from throughout Central Indiana. Patients travel to us from Indianapolis, Carmel, Fishers, Noblesville, Westfield, Avon, Brownsburg, Plainfield, Mooresville, Southport, Bargersville, and many other surrounding communities.
Take the First Step Toward Relief
You do not have to keep struggling, and you do not have to keep wondering whether something better exists. A free consultation with the AlphaOmega Wellness team is the first step toward understanding your options and finding the relief you deserve. Call us today at 317-300-4091 to schedule your consultation — we are available Monday through Friday and Saturday mornings. Our compassionate, physician-led team is here to walk alongside you on the path to feeling like yourself again.